Health Physics Corner, September 2025

Cyclotron Challenge: How Much Fluorine-18 Can be Generated?

Welcome back to the Health Physics (HP) Corner!

In this instalment, we are exploring Fluorine-18 activity. A Positron Emission Tomography (PET) isotope production cyclotron has a proton beam energy of 19 MeV and a maximum on target current of 200 µA. The nominal production rate of Fluorine-18 activity generated in an Oxygen-18 enriched water target via the 18O → (p,n) →18F interaction using 19 MeV protons is approximately 14 GBq µA-1.

Question 1

What is the maximum possible Fluorine-18 activity that can be generated using a 3-hour irradiation?

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Question 2

What would be the approximate unshielded effective dose rate at 3 metres from the target during irradiation?

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Recommended references

  • IAEA TRS465 Cyclotron Produced Radionuclides: Principles and Practice
  • IAEA TRS468 Cyclotron Produced Radionuclides: Physical Characteristics and Production Methods

Jeff Sandeman

Jeff describes himself as “a grumpy old curmudgeon” who retired from Canadian Nuclear Safety Commission’s Accelerators and Class II Facilities Division in January 2021 after 17 years with the division. Prior to that, he spent 20 years at CancerCare Manitoba, the last few years of which he was the radiation safety officer for the radiation therapy facilities.

Throughout both careers, he was blessed with opportunities to explore a very broad range of radiation-safety-related topics, including non-ionizing, diagnostic X-ray, nuclear medicine, medical radiotherapy, cyclotron isotope production, and even high-energy research accelerators. For some strange reason, both institutions also allowed him to teach on topics such as radiation protection fundamentals and radiation shielding design, and to mentor (corrupt) young staff. The highlight of his professional life came in 2020, when CRPA awarded him Richard V. Osborne Founders’ Award.

Now that Jeff is retired, he spends most of his time attempting to golf (very badly), making sawdust in the basement (woodworking), or collecting dirty bits of paper (a.k.a. postage stamps). He loves single malt scotch whisky, of which he has far more bottles than his liver can possibly survive. He continues to dabble in radiation protection and has maintained his membership with CRPA (usually after 18 notices to renew, as he’s growing a bit forgetful in his old age).

 

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